You can roll and drive at the same time with a few minor considerations. Any saftey related trim that you remove, like side mirrors will make it tough to drive.

I did my car over a 3 month period of on and off painting and I found that what I learned during the first two or three coats, I'd forgotten during the time that lapsed between them and coat 4.

Other than these issues I don't see why you couldn't drive it and paint it at the same time.