Since Feb 2020 Dr Ralph Baric of UNC has advocated using drug named EIDD-2801 against Covid-19

Finally the clinical trial Phase 1 testing it has found in “extremely effective”

https://medicalxpress.com/news/2021-02-antiviral-medication-coronavirus-lab.html

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Publishing their work in Nature, scientists at the UNC School of Medicine and UNC Gillings School of Global Public Health tested how the orally administered experimental drug EIDD-2801 halts SARS-CoV-2 replication and prevents infection of human cells in a new in vivo model containing human lung tissue.

They found that the drug was extremely effective and preventing and treating SARS-CoV-2 infection.
Phase 2 and 3 clinical trials are ongoing to evaluate EIDD-2801 safety in humans and its effect on viral shedding in COVID-19 patients.

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EIDD-2801 is expected to cause birth defects in pregnant women