The COVID-19 Prevention Network (CoVPN) today announced two Phase 3 trials to determine whether monoclonal antibodies (mAbs) can prevent SARS-CoV-2, the virus that causes COVID-19. The first trial, CoVPN 3501, will evaluate LY-CoV555, an Eli Lilly and Company mAb to see whether it can prevent SARS-CoV-2 infection among people living or working in skilled nursing and assisted living facilities. Scientists from the National Institute of Allergy and Infectious Diseases Vaccine Research Center and Abcellera Biologics discovered LY-CoV555. The trial will enroll up to 2,400 participants in the U.S. who will be randomized to receive an intravenous infusion of LY-CoV555 or a placebo. The second trial, CoVPN 3502, will evaluate REGN-COV-2, a Regeneron Pharmaceutical double mAb combination, to see if it will prevent infection among household contacts with close exposure to someone recently diagnosed with COVID-19 that has been sustained for at least 48 hours. The study will enroll approximately 2,000 participants in the U.S.
