No I would not make any holes since both these components are aluminum already and need to be strong in their function. Sometimes you have to concede to the loss of weight to keep strength in those places.
One time long ago, I helped a certain fast GS 455 Buick in lightening the load. After I described what he could theoretically do, he went ahead and cut too much off the quarter C pillar supports. The car started buckling and steering all over the place.