One signal from the computer can fire one coil and that coil can fire one plug or many depending on how the coil is desighned not nessacarily how the computer is deighned. The LS computer fires 8 individual coils and those 8 coils fire 8 plugs. The hemi has 8 coils that fire 16 plugs, the computer only has to fire 8 times to fire those 16 plugs so there is no reason to get rid of 1/2 the plugs just because you run an LS computer, the computer does not know it is fireing 8 plugs or 16 because the coil takes care of fireing 2 plugs when it gets one signal from the computer.

The Hemi coils fire one plug in the cylinder below it and one on the oposite side of the firing order. There are kits to make it just fire the two plugs in one cylinder.

The only complicated part to figure out with an LS computer is the cam and crank signals are gonna be different.