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Not really, the cheapest will be the one that the owner can do most of the work like head porting, valve job, the assembly, the tunning, the selection of the right parts, building the oil pan, oil pick up and so on. That would be the cheapest and, believe me, at 750 hp the small block would cost less money than a Big block because a set of W9 heads are less than half the price of a B1 head for a big block, but still both of them are Mopars so they are both ok in my book.

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This is true for both type engines, the more work you are capable of doing yourself, the more money you $ave. One important note though, although 750
hp smallbocks MAY be cheaper to build, in some cases, you have to look at the intended usage of that motor at that power level and what type of chasssis it's going in (street/strip car, all-out
drag car, circle track racer, truck, boat etc.) that also determines cost!! This is the same for the 750hp Big Block especially the RB's, since they have a tendancy to have "main cap walk" at that power level or beyond. This makes preventive measures slightly costly, by either starting out with a fresh foundation (improved design block), slick machine work/parts on the older production blocks or adding MORE cubes (stroking) to keep the rpms at a "streetable" (6500 rpm or below) level to offset the stress found at the higher rpms with that amount of hp. IMO they're both
not cheap to build as the hp dial is turned up.
Go cheap if you want, you'll just pay more later
replacing that engine part or maybe the block.