The most potential is going to be from a w8/48 degree deal, but frankly, i have personally not yet seen anything in that configuration NA that runs near what you would "think it should"
Dont know if nobody has hit on the right combo or what, or maybe there are cars out there i dont know of.

If i was going to make " for sure" big power, i would probably use the indy raised port 245 cnc deal on a 48 degree block,430-450 cubes, with lots of compression, big roller, pro systems dominator, light rings, good evac system, etc.

I would think the above combination, well sorted out, would propel any 3000 pound ish car into the 8's easily