2006 Ram 3500 DRW My truck has 460,000 miles on it. like others say stay on top of the maintenance. I replaced my injectors at 400,000 but have had good fuel filters on it since new. last set of tires lasted 55,000 miles on the front and the DRW are still going at 65,000. Wheel hubs/bearings go out but usually have lasted about 100,000 miles.