4+ inch stuff I typically won't spray or boost, side loading increases with cylinder pressure regardless of stroke or rod ratio so (obviously IMO) if you have long stroke short rod combo it's a little harder on the block with your normal cylinder pressure.

I like the 4+ inch motors when I'm looking for a true Big block 'behind the wheel' experience and where you run good (but not necessarliy "great") heads that limit the RPM (and more importantly piston speed) to a moderate (5800-6200 ish) range.

If you're boosting or spraying, I keep the stroke shorter and the rods longer, if I'm looking for a dual/purpose motor with Longevity. That said the +4 stuff works very very well on the street when set up for the purposes I described above. Torque motors are sweet on the street! Imagine a blueprinted 440 six pack....but with an 1850G bobweight and 100+ less poundage on the nose