Will a stock block handle the 4.25 crank in a low RPM torque engine?

Cuda, -70
Valiant-65 AWB,
Valiant Signet200 -65 Topchopped dragcar.
Topolino Fuel Altered.
NostalgiaFED Sold,
SuperComp Bantam Altered, Sold
Ex Harlan Thompsons Nitro funny car American Graffiti Sold,