I'll add to what others have said. The benefit of EFI is adaptability to changing conditions. Going cross country, you are likely to see altitudes >7'000 ft as well as sea level. Hot and freezing. Sometimes 10% ethanol, sometimes straight gas and sometimes in between. EFI can handle it all and keep the engine happy.

I drove my EFI wedge from IL to CA and back in a week. Last day on the way out I fired up in Flagstaff (~7,700 ft) on the first freezing morning of the season and later the same day was driving along the Mexican border at 90 F and sea level. The car ran great all the way.

Also the fuel supply matters a lot... in tank pump with baffles or remote sump fed by a low pressure pump works great. In line high pressure pump alone does not work well.