Feets is pretty much bang on with what he said. And for me, EFI all the way. My next 340 will be procharger, MPFI & Coil packs. My procharger in my 00 4.8L Silverado with a 100% stock engine running 6.5lbs makes 369 whp. Could never do the same with a old-school carb & stock(ish) 283 for example.
I made more than 369 whp with 8 psi blowing through an old school carburetor. You can do that.
However, the engine and I were both FAR happier with EFI.
BTW, the FITech throttle bodies can easily handle a common blow through setup on a 340.