Yes you can but I 100% recommend you go with the 2.200" BBC sized rod journals as it typically gives you even better crank to rod clearance around the bottom of the bores than the typical 4.15 stroke/2.325" journals and a 7.100" rod will lighten the pistons up quite a bit as well.

Hemi's already have the 1/2" pick up so the only thing you might need to do is clean-up/smooth the casting around the pick-up tube where the pick-up threads into the block.