I have gone 10.30s at 3450 lbs with a stroked (535) rb, 11/1 compression and a 590 cam with 1.7 rockers. I doubt it will take much more than that to go 10.50s at 3700 (?) lbs. That motor had ported 906 heads (280 cfm flow tops?), and pistons way down the hole. Fairly cheap stuff, from my perspective. With the availability of cheap heads that will flow 300 cfm with nothing more than a bowl port, I don't see how a small block can compete. Even if you have heads that flow as well, less cubes will raise the rpms. My deal was shifted at 5700 rpm. I doubt a small block stroker can compare to that. A very tight converter and a set of 3.54 or 3.73 gears and you should get there. I ran 4.10s with a 33 inch tall slick to go 131 mph with that 535.
You just can't beat big cubes for a streeter.