I've run the Sniper on a dual plane intake. It works just fine on a dual plane but it might work better with a small open spacer. There isn't a big difference between fuel/air flow with a throttle body and a carb. In both cases you have a mixture of air and fuel flowing out of the base and into the manifold. So whatever works with a carb tends to work with a throttle body.

As far as your other point on EFI performance you are correct, EFI will work much better in terms of automatically adjusting the air fuel mixture for different altitudes and weather conditions. Throttle body EFI will not make more power than a good carb but it should provide better driveability, especially if you add a Hyperspark distributor and use the full computer controlled timing feature.

The data logger is a huge advantage which most people never even talk about. Once you learn how to use the data logger you'll be able to solve all sorts of issues that have nothing to do with the EFI system. A super Sniper with the extra inputs can be used as a simple general purpose data logger. I use mine to monitor oil pressure, fuel pressure and crank case pressure. You can also monitor pressure in the cooling system or brake pressure or line pressure in an automatic transmission.