The problem is getting parts. Unless you have the ability to make them, or are able to find parts in useable condition, you are going to have a tough time. Im building one for my early hemi. Doing something odd though... using an overdrive version, so the parts up front are not really available. I also plan on using a transbrake valvebody for holding the car in the beams. (Clutch pedal release switch)
Im making 3 input shafts out of 300m. The cost of the extra two is minimal.
With the internals built like a good modern race TF, there is no reason I can think of that would cause any concerns of explosion.
A well built 727 will take that power without issue. Finding an existing clutchflite input shaft that will hold up to that power will be your stumbling block.