Just for fun how about a 70's street machine formula. Stock 426 including pistons, heads etc. Now bolt on a set of headers, tunnel ram with twin 660's or 750 doubles and a 650 lift solid cam. Something like that ran deep into the 11's. Guys did it all the time.
Tuning the carbs on a tunnel, no different than a 440, setting timing on the Hemi, no different than a 440, setting the valves on a Hemi, no different than a 440. Oh wait, install new plugs on the Hemi, hey thats a lot better than burning your hands on those 440 headers at the track between rounds...

Sheldon