ANYTHING you can do to straighten the pushrods out will be beneficial in the long run. FWIW I run offset lifters in my Predator with what most here would consider and insane amount of open pressure and ZERO issues. We went to extremes to make the pushrods as straight as possible and the 9/16"
double taper pushrods required a good deal of clearancing in the block. I have done the same with my -1 engines over the years as well. One thing many seem to miss is pushrod length as well, RARELY can you use the same size pushrod on each valve with offset rockers or lifters.