I have run a 4.15 x 4.375 499, went 9.30s at 3000 lbs with unported 440-1 heads.
If I had to do another low deck stock block again it would have the following; 512 cubes. The lightest rotating assembly I could cook up. along with aluminum main caps and a center counter weighted crank. The center weights spread the stress out where it belongs, to all the bearing journals more evenly.
Fill the block to start. Find the shortest lightest piston that will fit with an off the shelf aluminum rod.
Make darned sure my tuneup is conservative to start. I don't want any possibility of detonation.