My old combination went (in good air) 11.77 @ 115 in my 69 RR. It was a very mild, completely streetable, combination. I used to get almost 15mpg on the highway if I drove it gently.

MP 484 hydraulic cam
Stock E-heads
440 .030 over - stock lower end
10:1
Six pack with QF metering blocks
3:91s
hooker super comps 1 7/8"
Its a 4 speed car but I was using a 727 instead.
tight 10" converter

It ran great for years. I could drive it to the track, race, and drive home if I wanted. It would have been faster and less expensive with a single 4 and a Performer RPM. Eventually, one of the 40+ year old, stock rods failed and that was that...