Which spark box are you using?
The only thing i have ever had go bad that killed a ton of ET was a Digital 6 box. Took half a season to find the problem. Swapped it and car came back.
It would cause a miss in second and third gear was the symptom


69 Dart GTS A4 Silver All steel, flat factory hood, 3360race weight
418 BPE factory replacement headed stroker, 565 lift solid cam
Best so far, low 10.30’s 1/4
1.41 best 60 foot
6.56 at 104.17