The Carter/Edelbrock carbs have small fuel bowls where the floats take up a good percentage of the space in the bowl, and this makes them pretty sensitive to the fuel level in the bowls, but there is no easy way to see and adjust the float level like on a Holley. So you have to run the fuel pump or engine to fill the float bowls, pull the carb top off, check the fuel level, and adjust the floats if needed, then put the carb top back on, and repeat as needed.
Then if you are not careful tuning, and just throw different metering rods at it you can really upset the fuel metering as some rod changes can be like several jet sizes different, and the step size differences are all over the place. There are over 30+ different Edelbrock metering rods, and several more Carter metering rods to choose from with metering rod step size differences from 0.0000" to 0.0380". Considering each jet size change is 0.003" a single rod change could be the same at 10 or more jet sizes.
Then there is only the single accelerator pump, discharge nozzle and the AFB has the non-adjustable secondary opening rate. Also, only offered in a limited range of CFM ratings. I think all come with a choke too?

There is nothing really wrong, but they can be a challange to tune them, and this dosen't even compare to a higher end 4150 or 4500 carb that has adjustable (screw-in) restrictions, air and emulsion bleeds.

Carb comparisons on a drag car can be misleading because the carb is only operated at idle and wide open throttle in usually warm weather, not to mention most drag cars have high stall converters or launch at a high RPM so the secondarys will come in really quick because the engine is always operating at high RPM.

The Carter/Edelbrock carbs do seem to usually work well on street cars out of the box (if the floats are adjusted correctly.) Most have electric chokes for cold weather operation, and they are less expensive than the Holley type carbs.

Other reasons the Holley carbs are referenced here more (in the race section) is many of us are running 950+ CFM chokless race carbs.