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Ok, lets do some math...

...
Take the 3/8" diameter
So 3.1415 x .375"^2 x 100"x .0267lbs/in^3= 1.17 lbs mass




1. Area = pi*D^2/4, your volume calculations are 4X too big. 2. You're using solid mechanics math on a fluid mechanics problem.
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There are two separate issues and some are confusing them. One is the acceleration of a fluid and I've explained that one previously, the size of the line isn't an issue. The other is the pressure loss from fluid flow through the lines and fittings. This is the area people should focus on. First find your actual max. flow rate and then calculate the velocity in the line and determine if you need a bigger line. See this page: http://en.wikipedia.org/wiki/Reynolds_number