As a builder, it's possible as others have stated. To get the most out of it will take some trial and error.

Also, some believe timing is a good thing. That's simply not true. That's negative work against the piston as it rises. We don't have instantaneous combustion so we have to have advance to complete combustion by around 15* after tdc. You want the least amount the engine makes power with. The better the quench, with good compression, the less advance you will need. Then you have other factors like operating temp, DA, and when intake valve closes as the piston rises from bdc.

With a custom engine, whatever the customer wants...