I would say it's possible but why?

When you run higher compression you will get slightly better miledge and you can run almost 1 full point higher on premium than cheapy crap. It will also make more power and TQ and you will feel better when you try to

I did this on my MPG experiment engine and it basically pays for it self. It also is nice because thease type of builds don't get great miledge so you won't have to stop to fill it quite as often