I don't think the most jaded wedge fan will attempt an argument regarding flow per area. A well ported 6.1 will have a better flow coefficient than an all out race wedge head. And, thats still an OE casting.
I've been told,and have read how the 426 has this inefficient cumbersome valve train geometry that you just have to live with. I've got a buddy in Ga. who has much quality time with max lift Big Chiefs, Stage V hemis and Sonny's symmetrical heads. He tells me the Stage V had the most trouble free valve train of the bunch. It's noteworthy to mention that the rocker system for the Sonny's head was about the same price as the one for the hemi.
Not an argument to put one over the other. It's just to clear up some misconceptions that seem to follow hemis around.
The question was answered at the start of the thread. Run the one you like.