As said it all depends on what you want to do with it. A stroked small block is dynamite in a small package with plenty of power for the street. It also puts less weight on the front end and leaves more room in the engine bay for easier access to stuff (the headers were a joke to drop into our small-block E-body) not to mention more room in the engine bay equals more air-circulation for cooling.
Now for a drag-only car I would go big block.