I spent a lot of time setting up the valvetrain and I' can say the weight of the lifters doesn't seem to have any adverse effects on the motors ability to rev, it hits like a comp eliminator motor. My lifters are the Cranes that became very desirable and hard to get once Crane filed for Bankruptcy back in the early 2000's.

I don't think the Bullet cam I run would be ideal for your lower compression and overdrive, I do believe the 102 ICL (+6 advance) I run is one of the keys to this combo working so well.