Typically the guys I've worked with over the years considered equal tire sizes as a square set-up without consideration of the bolt circles or wheel offsets. It is the rarity that one runs into mixed bolt circles on a vehicle. I have seen it it, but it isn't common. However, if you do have alternate bolt circles in your hubs, all you really loose is the ability to easily rotate tires to any position. In a car turning right and left, I don't see that as an issue on the same level as a car that only turns one direction that may be running alternate diameters right to left.

Are replacement hubs in a square bolt pattern more or less expensive than the wheels under consideration and which methods serves the long term goals best?