I just completed a Sniper install on one of my cars last week. Wasn't really sure what to expect since its 500 Cubic inch engine, 12 to 1 Indy 295 CNC SR heads with a 272/275 @ .50 solid roller cam and a Indy dual plane. Maybe 5 to 6 pounds of vacuum at idle... I'm using the MSD distributor with the adjustable rotor for timing control. Took a while to get the idle dialed in. I idle it pretty high at 950rpm, but I idled it high with a carb to keep a lot of oil moving around. So far I'm very impressed with the system. Throttle response is great and really like the drivability of it. Wasn't sure how the dual plane would work and I do have a 1/2 inch spacer under the Sniper. I have a nicely ported 337 manifold on the shelf if I want to change it up, but this is 100% street car that will never see the track and I like the torque of the dual plane.

I still have some tuning to dial it in further and I'm doing all the tuning through the Sniper software as opposed to the hand help unit.

To the OP I don't think you will have any issues with that combination.