Not running E85, but if you have an electronic injection system capable of self learn, you should have no issues. But a carb is another story, they don't self learn and yes you need to jet for different alcohol levels. I had a buddy that used E85 in a circle track car, he purchased E85 from a regular race fuel distributor, because the pump E85 changed so much. You may need to change jets for weather conditions, so alcohol content would be a bigger need. In the old days we used a air density gauge to jet alcohol injectors for the weather and altitude, they have software to calculate stuff like that now. But I am not sure if they make it easy for alcohol levels. The second link explains a little why you need to change jets for different levels of alcohol.
https://www.performancetrends.com/Weather-Wiz.htmhttp://www.thecarburetorshop.com/Ethanoluse.htm
