On the two stroker motors I dynoed that had Indy heads and a x-ram intake with edelbrock 750 carbs, when jetting for best power, I ended up with jetting quite a bit richer than the as delivered edelbrock jetting.
One was 675hp, the other was 745hp.

One of those came to me with torched head gaskets from being run too lean.....and those carbs were richer than stock as well.