Although "too big" does seem to mean different things to different people, I ran a .484 in a basically stock '69 383, A-body, 4-speed, 3.23 rear and it was a blast on the street.
Also the original Direct Connection "Engine" book mentions running the .509 in a Duster with an 8.5:1 400 and it was pretty quick (mid 11's?) been a long time since I read through that book though.