It would depend on whether or not a power adder could or would be used. If you need to go naturally aspirated, I would get one of the new Keith Black 4.6 in bore Hemi blocks and put a 4 and 3/4-in crank in it, some millennium heads, two dominators on a tunnel ram, and a big old roller cam. That should do it.
If you're going to run a power adder, there's about a million different ways to get there.

If you're going to race in one of the drag and drive power adder classes, you are going up against some serious competition. It seems that anybody with a junkyard LS and a couple of eBay turbos can make 1,500 horsepower. The naturally aspirated classes are generally have a little bit more low hanging fruit.