I think that would be an interesting build. The physically smaller Dodge Hemi (compared to Chrysler) might be a good fit for it. Not sure what style pan would be needed to clear the suspension but as I recall there were some different options that would fit the 241.

1957 Plymouth (Hemi, Dual Quads, A833 4 Speed 9 1/4 w 4.10) Sold
1937 Dodge Pickup (Hemi, 6X2 intake, 46RH, Dana 60 w 4.56) Sold
1968 Plymouth Valiant 2dr sedan (354 HEMI, 46RH w/4.30 gears)