Struts are lighter with fewer moving parts. Framerails are lower and out of the way. On a big block Mopar, the oil system needs to be considered.

Handling on a drag car is not much of an issue. High speed stability is. Proper caster is the main concern.

I wouldn't put spindle mounts on a heavy car for a number of reasons - strength, available brake kits being the main ones.

My car was built with a-arms years ago to try to save a few bucks. Basically an aftermarket Pinto style deal. I didn't have it long before I wished it had struts, but it's light and a bit smaller than a B-body.