I've ran both types of cam drives but not back to back on the same motor with exactly the same cam timing, both worked well
My new almost all out motor will be similar yours, 4.500 bore x4.375 stroke in a Koleno high nickel cast iron block with a set of fresh B1-MC heads and around 15.0 to 1 compression on E85 with two Dominator carbs on a sheet metal tunnel ram, hoping for 1000 HP + at or near 8000 RPM