Mike,
Years ago I had a 340 my Dad put together for me in a duster. It had 10:1 with very little quench. It would knock like crazy on pump gas.

Shortly after being put together, it ate a flat tappet cam, and all of the metal went in the pistons. Rebuild the motor with another set of flattops, but this time at 12:1 with very tight quench (.035"). That motor would run on 93 octane ALL DAY....

So I'm not sure what your plan is, but I was able to raise compression almost 2 full points, AND have it run better on 93.