I run a motorplate and love it. It makes everything easier...engine R&R, clearance for headers/oiling system, and a place to mount everything up front.
The vibration difference is minimal IMO.

CHIP
'70 hemicuda, 575" Hemi, 727, Dana 60
'69 road runner, 440-6, 4 speed, Dana 60
'71 Demon 340, no drivetrain, on blocks behind the barn
'73 Chrysler New Yorker, 440, 727, 8.75
'90 Chevy 454SS Silverado, 476" BBC, TH400, 14 bolt
'06 GMC 2500HD LBZ Duramax