I did a 383 for a guy with that hughes cam, lifters, and springs, straight up, pistons a mile down, milled heads got it to 8.9 to 1 measured, pocket ported heads, old weiand dual plane, 100% stock older 3310, 18 degree in dizzy, 20 on the crank, exhaust manifolds and it runs fine. Its a bad combo but a bunch of old parts he wanted to use up, it sounds meaner than it runs, but will idle all day on cheap gas no matter how hot it is, which is what he wanted. Best advice all the initial timing you can get.