dave......this might give you a little example of cam/compression change had on my 4 inch w5 combo...

I went from a 260/266 flat tappet cam 416 with 11.8 compression w5 headed combo that ran a best ever of 10.38 at 129 and change.
Swapped in a 422 shortblock, that ended up being 13.3 compression, and added a 700 lift roller that was 273/280@ 50 cam shaft.
same heads, headers, carb, intake, gears and convertor. So pretty much the only real effective changes was going from 4.07 bore to 4.100 bore, the compression bump and the bigger roller over the smaller flat tappet. Rest of the combo remained the same.
Best with those changes was 9.85 at about 135. So about 5.5 tenths and 5 or 6 mph.
The new shortblock of course was fresh, and had 043 ring pack, but it yielded a significant difference. Picked up about a full tenth in 60 foot, suspension remained identical, as did tires/wheels etc.
Hope this might help.

should probably also add, current owner of car took off 150 pounds,down to 3200 pounds freshened shortblock again, went to a more aggressive roller that is 276/282 I believe,same lift or close, and bumped compression to just over 14 to 1, and picked up additional 5 mph and 2 tenths, with everything else unchanged..same gears,tranny convertor, carb, intake, headers, suspension etc. The car really seemed to like the much more aggressive profile of the camshaft, over the quite mild profile I ran that was easy on springs and was somewhat streetable. All three cams, the flat tappet and the two rollers were all specc'ed by Dwayne Porter.