I use a lot of heat to keep the oil clear on methanol, warm to 200+ before shut down and be sure and crank it with ignition on/fuel off to fire what drips out of the lines.
Plugs, once checked, I go to the hotest one and tune by that to stay a tad rich, then I only need to check one plug if I make a tuning change.
Oil pan heater, or similar warming device will save fuel. Methanol is definitely the most powerful of the three, having more torque in the lower rpm ranges. I believe the differance is e85 is 2 percent better than gas, methanol about 2 percent better than e85, M5 by VP is faster yet but costly!