If you have flow sheets for that bore size on both sets use the best flowing pair for your build
1000 HP shouldn't be hard to make with that size C.I.(1.65 HP per C.I.) and a good set of heads, intake, carbs and cam to match your goals
Give us more details on the specs on your build
I'm going to be starting a 555 C.I. drag race motor next year for myself that is a Koleno high nickel block with a 4.500 bore and a 4.375 stroker old top fuel crankshaft with full counter balances on all throws, set of B1-MC heads with all new titanium valves and a paired shaft rocker arm system with a sheet metal tunnel ram with two 1050 CFM Dominator carbs on race gas, maybe have them converted to E85 later
I'm shooting for 1.75+ HP per C.I. on this build
I built a B1 bracket motor for a customer several years ago that was 4.495 bore with a 4.25 stroke with a cast single carb intake manifold, it was not a all out effort and it made 920 HP at 2800 Ft with a not so good carb.
On your deal with good parts a 1000 HP should not be a real challenge