I have done it once as a band aid.
383 with a performer intake.
the holley I had on it crapped out. so I reversed that 2 to 4bbl adapter and put the 2bbl on the 4bbl intake like you sugguest.

it ran fine enough till I could get the rebuild kit in and redo the carb.

didn't see any issues doing it.
it does pick up the carb that adapter height. so if you have clearance issues, it might make it worse.