Definitely need to differentiate between fuel injection and carburetion.

You can get the fuel to atomize, mix and distribute evenly at pretty much any rpm with FI.

A carb is going to require some velocity, which is why the idle circuit has to run a bit richer to compensate, more so with a square bore like a Holley.

Shoot for 2000+ rpm and you'll be happy with the throttle response and fuel economy (relatively speaking anyway).

If I make the Power Tour next year, I'll be putting in my 2.76s and rolling about 2200 rpm at 70 mph. Did the same thing in my 440 Six Pack Challenger in 2010 and averaged over 16 mpg. No vacuum advance either. I'd expect better with my T-quad equipped 360/410 stroker in the Road Runner. I got over 14 mph with 3.55s on the way to Nationals this year.