I believe its been done sucessfully. You'll wind up with a short rod/long stroke engine and a "decent" compression height piston. A good aftermarket rod would be needed to hold up reliably. Piston side load will be on the high side. Other possile combinations are:
4.15 stroke/6.76 Chrysler rod: longer rod, short piston, higher rod ratio
3.9 stroke/6.7 BBC rod: longer rod, "decent" compression height piston. Proven durability in street & street/strip application.
4.25 stroke/6.535 BBC rod: max practical displacement with stock low deck block (my opinion), decent compression height, short rod ratio.
All these combos have trade-off's. Depending on where you're trying to get to with this engine, I'd choose one of the 3 above over the long stroke/short rod combo. My