Last time I drove my car the upper edge of the glass came out of alignments. It came in towards the interior of the car by about 1". It is not loose or wobbly and still rolls up and down nicely. I just can't roll it up all the way now because it interferes with the top weather strip. I haven't pulled the panel off yet but was hoping to hear from someone out there what to expect. Thanks!

Check the main channel adjustment at the bottom of the door. It's about 2/3 up the door toward the front of the car. If the adjustment is all the way toward the outside of the car that's your problem.

Everything else will require you taking the door panel off.