Make a couple of pulls on the dyno to warm up the fluids if your not driving the car to the dyno from very far. make two or three pulls to see if it repeats, if it repeats within 1.0% then start tuning
If it doesn't repeat within 1.0% try and figure out why and fix that first and then go to town on making more power
It is always safer to jet up and move the timing back to start with, if that looses power go the other way a little at a time
try and change one thing at a time and then make another pull, have fun
Let us know your results