I run a 496/440 stroker, currently with 4.30 and 727 with 3000 stall. I had a 28" tire, @55mph 3000rpm. Went to a 29" tire and dropped approx. 150-200 rpm at same speed. I plan to switch to 3.91 myself and have a lil more driveability in the car. The 3.73 is also an option as well. The more cubes(stroker) = more torque. I dont think you need 4.30 as others suggested here youd run out of motor at the end of the strip. Keep the motor in its powerband longer other then way upstairs where you may come up short. The taller tire (29x11.50x15 Hoosier DOT slick 15x8"rim) in itself helped me a lot. Slightly taller and more rubber on the street. Blows away drag radials.
Try a dyno, possibly will find your powerband target zone and help you decide better.
Good luck.