I've used what you are describing: 800 DP spreadbore Holley, fresh stock rebuit 440, heavy car, 3.23 and an auto with 12" stock converter. The car ran great. Fried the tires at will at any speed in 1st gear. That was 20 years ago and I still have the carb mounted on the intake with fuel line and air cleaner sitting in storage ready to go. I've loaned it out to others as-is and they all had very good results as well.

This was with a stock cam, factory spreadbore intake, and exhaust manifolds, but the engine was fresh and an honest 10:1 CR. We did run it on a low comp. stock-like 440 GTX and it ran very well too.